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Grand Est has 7,665 e-commerce businesses (7.5% of the national market), ranking as the 5th digital region in France. B2C dominates (64.4%) while WooCommerce (45.2%) and PrestaShop (25.5%) are the leading CMS platforms. Bas-Rhin, Haut-Rhin, and Moselle concentrate nearly 60% of businesses, spanning professional services, B2B industry, and craftsmanship. Services and B2B dominate, complemented by local crafts and tourism, reflecting the digital modernization of a cross-border industrial region.

Nouvelle-Aquitaine has 10,877 e-commerce businesses, representing 10.6% of the national market, ranking 3rd among French digital regions. B2C dominates (62.0%) while WooCommerce reigns as the preferred CMS (47.1%). Gironde, Pyrénées-Atlantiques, and Charente-Maritime concentrate more than half of all businesses, illustrating a balance between professional services, coastal tourism, and agribusiness. This territorial dynamism reflects the rise of an innovative ecosystem, blending wine tradition, nautical industry, and promotion of local produce.

Nouvelle-Aquitaine has 9,719 e-commerce businesses, representing 9.5% of the national market, ranking as the 5th digital region in France. B2C dominates with 60.9% of businesses while WooCommerce leads (48.7%). Gironde, Pyrénées-Atlantiques, and Charente-Maritime concentrate more than half of all sites, illustrating a balance between professional services, coastal tourism, and agribusiness. This dynamism reflects the region's territorial roots and digital innovation. All 12 departments reveal varied and noteworthy sector-specific characteristics.

Pays de la Loire has 5,789 e-commerce businesses (5.7% of the national market), ranking as the 7th digital region in France. B2C dominates (61.0%) and WooCommerce reigns (50.4%) as the preferred CMS. Loire-Atlantique, Maine-et-Loire, and Vendée concentrate half of all businesses, reflecting a balance between dynamic metropolitan areas (Nantes, Angers) and innovative rural territories (food industry, manufacturing). This territorial dynamic highlights both an integrated and diversified digital ecosystem. B2B (17.6%) also remains well established.